Borrelioosi/immuniteetti

[soijuv]

Aiemmin on ajateltu että borreliabakteeria kohtaan ei kehity lainkaan immuniteettia. Artikkelin mukaan näyttää kuitenkin siltä että mikäli uusi tartunta on aiemmasta, samantyyppisestä bakteerikannasta, on mahdollista saada vähintään 6v pituinen immuniteetti. Ongelmana on, että useimmiten uusi tartunta on uuden bakteerikannan aiheuttama eikä sitä kohtaan ole muodostunut immuniteettia.


Evidence for strain-specific immunity in patients treated for early Lyme disease

Camilo E. Khatchikian, Ph.D., Robert B. Nadelman, M.D., John Nowakowski, M.D., Ira Schwartz, Ph.D., Gary P. Wormser, M.D. and Dustin Brisson, Ph.D.

Infection and Immunity, online before print, January 13, 2014.

http://doi.org/10.1128/IAI.01451-13

Abstract

Lyme disease, caused by Borrelia burgdorferi, is the most commonly reported vector-borne disease in the United States. Many patients treated for early Lyme disease incur another infection in subsequent years, suggesting previous exposure to B. burgdorferi may not elicit a protective immune response.

However, identical strains are almost never detected from patients who are infected multiple times, suggesting that B. burgdorferi exposure may elicit strain specific immunity. Probabilistic and simulation models assuming biologically-realistic data derived from patients in the Northeastern US suggest that patients treated for early Lyme disease develop protective immunity that is strain specific and lasts for at least six years.

http://doi.org/10.1128/IAI.01451-13